Effects of probenecid, sodium salicylate, 2,4-dinitrophenol and pyrazinamide on renal secretion of uric acid in chickens.

According to classical concepts, uric acid is presumably filtered at the renal glomeruli andl reabsorbed but not secreted by the renal tubules in man (Berliner et at., 1950). Recent work (Y#{252} and Gutman, 1959) suggests that uric acid may, however, be both secreted and reabsorbed by the tubules. In this species probenecid and salicylates may either increase renal excretion of uric acid, and the ratio of uric acid clearance to glomerular filtration rate, or decrease these values depending on the dose given (YU and Gutman, 1955). In rabbits given exogenous loads of uric acid, the clearance of uric acid is stated to rise above that of creatinine (Poulsen and Praetorius, 1954). In this situation both probenecid and salicylates uric acid depress the . . clearance ratio (Poulsen, creatinine 1955). In Dalmatian dogs uric acid appears to be secreted by the renal tubules and probenecid uric acid depresses the . . clearance ratlo (W olfson creatmine et at., 1950; Beyer, 1954). There is conclusive proof and acceptance by workers in renal physiology that uric acid is excreted mainly by renal tubular secretion in the chicken (Mayrs, 1924; Smith, 1955). For this reason we have used chickens for studies of the effects of certain drugs on the secretion of uric acid.